2022 Summer Intern - Radioligand Characterization
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Job Description
Takeda Pharmaceutical
About the role:
Takeda's summer internship program blends real world experience with an extensive overview of the pharmaceutical industry. Knowledgeable mentors will provide guidance as you gain professional hands-on experience. The summer internship program is 12 weeks in length and offers a unique perspective into a world-class pharmaceutical company. Our internship program also provides you the opportunity to network with people at Takeda through various planned events and activities.
Project Outline:
Background: Disease on the clinical and molecular level occurs as a result of numerous abnormal cellular processes, many of which result in the build-up of proteins that are dysregulated, miss-folded, stick together, and/or cause the death of critical cells in the body. The cellular processes which lead to cell deaths include, for example, protein functional changes, alteration of the number of cellular proteins, or the location of the proteins. The Imaging group at Takeda aims to evaluate/use new and existing imaging reagents (radiotracers) to aid in the development of treatments for a number of diseases across neurodegeneration, gastrointestinal, rare diseases, etc. Non-invasive imaging methods can be used to diagnose and monitor disease, select therapeutic treatment dose, and show target binding in living animals including nonhuman primates and humans. To show the imaging tools are useful and specific for the intended targets related to normal and diseased states, characterization must be performed in post-mortem tissue systems.
Objectives: Post-mortem mammalian tissues will be used in experiments that will evaluate new and/or existing radioligands to study them in the target environment which is similar to in-life imaging in humans. Using post-mortem tissues from a variety of species, we will assess:
1) how well do the imaging agents bind to the site of interest (affinity),
2) how many sites of interest are present in the post-mortem tissue (density),
3) where (distribution) both new and existing radiotracers will stick (bind).
Collecting these types of information will allow for go/no-go decision-making regarding therapeutic compounds as well as the radiotracers themselves, de-risking them prior to use in humans.
The successful applicant perform experiments to collect data about radiotracer and target characteristics using radioligand binding and/or immunohistochemistry/Immunofluorescence staining methods in the newly established in vitro Imaging Lab.
How you will contribute:
- Deadline-driven with a high level of organizational and planning skills
- Strong analytical, problem-solving, and oral and written communication skills; he or she also has the ability to work well in teams, effectively manage projects, and present ideas clearly and concisely.
- Global mindset to grow in a diverse work environment
- Excellent communication and leadership skills
- Attend departmental and team meetings.
- A strong science background in applied laboratory science including wet lab experience and proficiency in pipetting technique is essential.
- Candidates should ideally have demonstrated interest in PET imaging with specific knowledge of, or previous experience with one or more of the following: radioactivity (eg. 3H and 18F, etc.), radioligand binding assays.
- An understanding of immunostaining methods and experience with cryosectioning of fresh frozen tissue samples is preferred.
What you bring to Takeda:
- Must be authorized to work in the US on a permanent basis
- Must be available full time (40 hours/week) a minimum of 12 weeks during the Summer months
- Minimum GPA 3.0/4.0
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Graduate, PhD student with at least one year of university studies before internship.
- The ideal candidate will be pursuing a Master’s or Doctoral degree in molecular imaging, receptor pharmacology, biochemistry or a related field.
- Return to university for at least one semester post-internship
- Takeda does not provide student housing or housing stipends
Salary & Location:
- Intern pay rate ranges are from $18/hour to $45/hour, depending on students level in their undergraduate or graduate program and level professional experience.
- Location is COVID-19 dependent, remote applicants may apply.
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Empowering our people to shine:
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.
This posting is made in compliance with Colorado's Equal Pay for Equal Work Act, C.R.S. § 8-5-101 et seq
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.