Cambridge, MA-based H3 Biomedicine (H3B) is a leading company in cancer genomics driven drug discovery, delivering on the promise of precision medicine. The company was launched in 2011 with an unprecedented $200 million in initial funding from Eisai, plus a continued ongoing commitment to fund H3B’s robust discovery pipeline and clinical programs. Now with three clinical stage anti-cancer molecules in active development, H3B is able to uniquely leverage distinct insights from cancer genomics and real-life patient data to advance its projects to clinical proof of concept and beyond. H3B embraces a novel business model in which it collaborates with Eisai, a leading global pharmaceutical company, to create a prolific drug discovery engine and partnership platform.

Join us for an exciting internship within H3 Biomedicine chemistry group.

We are seeking a highly motivated individual with background in organic chemistry and biochemistry. The successful candidate will contribute to the optimization and development of bioconjugation techniques.

Under supervision, the intern will contribute to new linker payload design, synthesis, and analysis. Techniques will include synthesis, chromatography, analysis (TLC, LC/MS, HIC, SEC etc.) and bioconjugation, among others. The intern will have opportunities to present research findings through written updates and oral presentations to the team.

The ideal candidate will be a junior or senior undergraduate, a recent graduate from an undergraduate institution, or a candidate in a master’s program. The candidate should major in chemistry or a similar field. Hands-on lab-based research experience is highly preferred. The candidate should be familiar with small molecule synthesis, purification and analysis. Experience working with peptide/protein conjugates or antibody drug conjugates is a plus.

Principal Duties and Responsibilities:

• Synthesis of linker-payload
• Bioconjugation of payload to the biologics peptide/protein/Ab
• Execution of analytical methods to characterize small molecules, antibodies and bioconjugates.
• Documentation of experimental and data using electronic notebook
• Present program updates and data at meetings.

Job Qualifications:

• Completed coursework in organic chemistry and biochemistry
• Undergraduate chemistry major with a strong academic record.
• Must have completed two semesters of organic chemistry laboratory coursework.
• Preference given to candidates who have performed independent undergraduate research as well.
• Familiar with standard analytical techniques (NMR, TLC, HPLC, mass spectroscopy)
• Experience with ChemDraw, Powerpoint and Excel preferred
• Strong communication skills

H3 Biomedicine requires all new hires to be fully vaccinated against COVID-19 and provide valid proof of vaccination as of their start date, to the extent permitted under applicable law. This requirement is a condition of employment at H3 Biomedicine, and it applies regardless of whether the position is located at an H3 Biomedicine site, field based or is fully remote. If you are unable to receive the vaccine for qualifying medical reasons (including pregnancy-related), or religious reasons (sincerely held religious beliefs), you will have an opportunity to request a reasonable accommodation.

H3 Biomedicine is an equal opportunity employer and as such, is committed in policy and in practice to recruit, hire, train, and promote in all job qualifications without regard to race, color, religion, gender, age, national origin, citizenship status, marital status, sexual orientation, gender identity, disability or veteran status. Similarly, considering the need for reasonable accommodations, H3 Biomedicine prohibits discrimination against persons because of disability, including disabled veterans.

H3 Biomedicine Inc. participates in E-Verify. E-Verify is an Internet based system operated by the Department of Homeland Security in partnership with the Social Security Administration that allows participating employers to electronically verify the employment eligibility of all new hires in the United States.